A recent study published in Neurology highlights the connection between severe sleep apnea and changes in brain structure, shedding light on how this condition could affect memory and cognitive health over time.
The Brain on Sleep Apnea

Researchers followed nearly 3,000 older Latino adults for a decade, using at-home sleep tests to assess breathing interruptions and oxygen levels. Brain scans taken during the study revealed that severe sleep apnea was linked to specific brain changes:
Hippocampal enlargement: The hippocampus, which plays a key role in memory, showed signs of inflammation.
White matter lesions: These lesions, often linked to damaged blood vessels, can impair communication between different areas of the brain.
Both of these changes are known risk factors for cognitive decline and Alzheimer’s disease.
How Does Sleep Apnea Cause Brain Damage?
Sleep apnea disrupts the airflow needed to maintain healthy oxygen levels. This lack of oxygen can lead to inflammation, vascular damage, and even neuroinflammation, all of which stress the brain. Over time, these effects may contribute to memory problems, mood changes, and increased vulnerability to Alzheimer’s-related brain changes.
The hippocampus is particularly at risk because it relies heavily on small blood vessels that are easily damaged during periods of low oxygen. Research has even shown that untreated sleep apnea can accelerate brain injury, including changes linked to Alzheimer’s.
Sleep Apnea: A Widespread Yet Underdiagnosed Problem
The scariest part? Most people with sleep apnea don’t even know they have it. In fact, up to 90% of cases remain undiagnosed. While loud snoring is a common red flag, not everyone with sleep apnea snores—and not all snorers have sleep apnea.
Other symptoms to watch for include:
Daytime fatigue
Snoring
Waking up gasping for air
Mood swings or memory problems
Frequent nighttime urination
Protecting Your Brain and Your Sleep
The good news? Early diagnosis and treatment can help protect your brain. Common treatments include:
Positive Airway Therapy: These devices deliver a steady stream of air to keep your airway open during sleep.
Oral devices: Custom-fitted mouthpieces can also improve airflow.
Lifestyle changes: Losing weight, quitting smoking, and avoiding alcohol or sedatives can significantly reduce the severity of sleep apnea.
Surgical options: In severe cases, surgery may be needed to improve airway function.
Beyond medical interventions, cultivating healthy sleep habits is critical. Deep sleep is essential for the brain’s waste-clearing system, which helps remove harmful substances like beta-amyloid, a protein linked to Alzheimer’s.
The Takeaway
Sleep apnea isn’t just a nighttime nuisance; it’s a serious condition that can impact your long-term brain health. If you suspect you or a loved one might have sleep apnea, don’t ignore the signs. A sleep study could be the first step toward better rest and a healthier brain.
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